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VOA慢速 肠虫病药物治疗方面取得重大突破

kira86 于2008-03-26发布 l 已有人浏览
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New Drug Shows Promise Against Worm DiseaseThis is the VOA Special English Health Report. Scientists think the

new drug shows promise against worm disease



this is the voa special english health report.

scientists think they are a step closer to a new drug to treat schistosomiasis. more than two hundred million people suffer from this parasitic worm disease. most live in developing nations in tropical climates. about ten percent of victims become seriously disabled from internal bleeding, iron loss, organ damage or other effects.

a team in the united states found that chemical compounds known as oxadiazoles can target an enzyme needed for the survival of schistosoma. this is the group of flatworms that cause schistosomiasis. 

the scientists tested oxadiazoles on laboratory mice. they found that one compound killed the parasite at every level of development – from larva to adult. the study also showed that the compound was active against all three major species of schistosoma worms that infect humans.

the national institutes of health supported the research. scientists from illinois state university and the chemical genomics center at n.i.h. reported their findings in the journal nature medicine.

biology professor david williams led the research. he says the schistosoma parasite needs oxygen to survive. oxygen use produces oxygen-free radicals that can destroy an organism. the worm has a protective enzyme. but professor williams says the experimental drug disables this enzyme, causing the worm to self-destruct.

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