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科学家发现大麻中含某种能治疗精神疾病的物质

kira86 于2018-09-13发布 l 已有人浏览
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英国科学家在大麻植物中发现的一种物质可以通过抑制病人大脑的异常活动来帮助精神病患者康复。
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Scientists Explore How Cannabis May Fight Psychosis

科学家研究大麻是如何对抗精神病的

British scientists have found how a substance in the cannabis plant acts in the brain to reduce abnormal activity in patients at risk of psychosis.

英国科学家在大麻植物中发现的一种物质可以通过抑制病人大脑的异常活动来帮助精神病患者康复。

Their findings suggest that the substance could be used in a possible treatment for the condition.

他们的发现表明,这种物质可以用于治疗这种疾病。

Cannabis, also known as marijuana, is illegal to grow, sell or use in many countries. Using powerful forms of cannabis can increase a person's chances of developing psychosis. But the substance the researchers studied, the chemical cannabidiol, appears to have the opposite effect.

大麻在许多国家种植、销售或使用都是非法的。使用强力的大麻会增加一个人患精神病的风险。但研究人员所研究的化学物质—大麻二醇,似乎有相反的效果。

Cannabidiol, or CBD, is non-intoxicating. That means it is unlike drugs or alcoholic products, which can affect the user's judgement or behavior.

大麻二酚,或称CBD,是不会让人中毒的。这意味着它不同于毒品或酒精产品,会影响使用者的判断或行为。

CBD is the same cannabis substance that has also been shown to help patients with epilepsy, a disorder of the nervous system. This led to the approval in the United States of a cannabis-based drug, a specially processed form of CBD, in June.

CBD同样也是一种大麻物质,但它被证明可以帮助癫痫患者,癫痫是一种神经系统发生紊乱的疾病。今年6月,美国批准了一种以大麻为基础的药物,一种经过特殊加工的CBD。

Earlier research at King's College London had shown that CBD seemed to block the effects of tetrahydrocannabinol, the intoxicating substance in cannabis. But how this happened was a mystery.

伦敦大学国王学院(King’s College London)早些时候的研究表明,CBD似乎能阻止大麻中令人陶醉的四氢大麻酚(tetrahydrocannabinol)发生作用。但这一过程是如何发生的仍是个谜。

Now, King's College researchers say they have more evidence of the health benefits of CBD.

现在,国王学院的研究人员说他们有更多的证据证明CBD对健康有益。

Sagnik Bhattacharyya and his team gave 33 young people capsules containing the substance. All 33 subjects were experiencing signs of psychosis, although they had not been shown to have the full-blown mental condition.

萨格尼克·巴塔查里亚和他的团队给了33名年轻人服用了含有这种物质的胶囊。所有33名受试者都曾出现精神病的症状,尽管他们并没有表现出完全的精神病状态。

The researchers studied images from the brains of the young people. They found that taking CBD capsules reduced abnormal activity in three areas of the brain: the striatum, medial temporal cortex and midbrain.

研究人员研究了年轻人大脑的图像。他们发现,服用CBD胶囊可以减少大脑三个区域的异常活动:纹状体、内侧颞叶皮质和中脑。

Abnormal activity in all three areas has been linked to the development of psychotic disorders, such as schizophrenia.

这三个领域的异常活动都与精神疾病的发展有关,例如精神分裂症。

Most current anti-psychotic drugs target the chemical dopamine. The brain uses dopamine to send signals from one nerve cell to another. But CBD works in a different way.

目前大多数抗精神病药物针对的是化学物质多巴胺。大脑使用多巴胺将信号从一个神经细胞发送到另一个神经细胞。但CBD的工作方式不同。

One major difference is that the body has an easier time dealing with CBD than other substances. CBD is less likely to cause harmful side effects, such as weight gain and other health problems linked to existing medicines.

与其他物质相比,人体更容易处理CBD。CBD不太可能造成有害的副作用,例如体重增加和其他与现有药物有关的健康问题。

Bhattacharyya told the Reuters news agency, "One of the reasons CBD is exciting is because it is very well tolerated compared to the other anti-psychotics we have available."

巴塔查里亚告诉路透社,“CBD的发现令人十分激动其原因之一是因为,与我们现有的其他抗精神病药物相比,它的耐受性非常好。”

There is an urgent need for a safe treatment for young people at risk of psychosis, he added.

他补充说:“目前迫切需要对有精神病风险的年轻人进行安全的治疗。”

The Institute of Psychiatry, Psychology and Neuroscience at King's College now plans a 300-patient clinical trial of CBD as a treatment.

国王学院的精神病学、心理学和神经科学研究所现在计划进行一项300名患者的CBD临床试验。

Researchers plan to start identifying subjects for the clinical trial in early 2019.

研究人员计划在2019年初开始为临床试验确定受试者。

The latest findings show the complexity of the combination of chemicals found within the marijuana plant. They come at a time when many countries are beginning to make their laws against cannabis less severe.

最新的发现表明了大麻植物中化学物质组合的复杂性。这些发现出现之时,许多国家开始降低对大麻的法律制裁。

I'm Pete Musto.

皮特·马斯托为您播报。

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