Psychedelic or "magic"mushrooms have been ingested by humans for over 9000 years.Even today,this naturally grown fungus is commonly used as a recreational drug.causing hallucinations,but how exactly does it work?The main psychoactive ingredient in shrooms is call psilocybin.When ingested,the body breaks it down into the active drug psilocin,which makes its way to the brain.
And here,it begins to prevent the reuptake of the neurotransmitter serotonin,increasing its activity.On top of this,psilocin actually has a similar chemical structure to serotonin,meaning it can also bind to and stimulate receptors in the brain.This amplified stimulation causes you to perceive and experience things without any real stimulus-also know as hallucination.
These can be of a varying nature,from visual to auditory sensations,or mystical and insightful feelings.And while the experience can be quite enjoyable,some users have reported very unpleasant episodes.These feelings generally last between 3-8 hours,but could feel much longer as the drug alters your sense of time.
Scientists have also suggested that the brain may temporarily rearrange itself by inhibiting normal brain activity and immediately creating new biologically stable brain connections.This,ultimately,makes it harder to determine reality from fantasy,and amplifies your intensity of thought which makes planning ahead and self conscious thinking almost impossible.
We also see activation in the hippocampus and anterior cingulate cortex which are associated with dreaming.Finally,specific emotional regions of the brain are chemically activated,which can lead to a sense of expanding consiousness.And because the drug temporarily alters the paths in your brain,"thinking outside of the box"becomes extremely natural.
In a famous US study,36 college educated participants were given psilocybin and observed in a laboratory.1/3rd of the participants reported the experience as the single most spiritually significant moment in their lives,with 2/3rds putting it in their top five.Two months after taking the drug,79% of the participants reported increased well-being and satisfaction.
美国一个著名的研究中 36名大学生志愿者,服用裸盖菇素 并在实验室中接受观察,三分之一参与者表示,这是他们人生最重要的精神体验,三分之二的人则认为这属于人生前五的主要时刻,服用两个月后,79%的参与者表示幸福感和满意提升了.
Friends and family were also interviewed and agreed with these claims But it's not all so positive-22% of the clinically tested individuals experienced fear and paranoia at certain points during their trip.And because of the state of their brains,these typically manifested as terrifying and uncontrollable hallucinations.
Though much is still unknown about shrooms,they're not considered clinically addictive and cause little toxicity to other organ systems.
In fact,a UK study found that they cause the least amount of damage-both to the individual and others-when compared to other recreational drugs.Ultimately,scientists believe the laws need to change around clinical testing of the drug so advanced research can be executed to fully understand both the positive and negative effects that this "magic"fungus has on our brains.