Study Suggests Virus Cause of Paralyzing Illness in Children
Scientists have found the strongest evidence yet that a virus is to blame for a mysterious illness that can quickly paralyze children.
The very rare condition, called acute flaccid myelitis or AFM, is similar to the polio disease. The first reports of the disease came from the American state of California in 2012. Since then, the U.S. has experienced an increasingly bigger outbreak every other year, from late summer into autumn.
Doctors have long believed that certain viruses known as enteroviruses caused AFM. But they did not have enough evidence to prove it.
So researchers tried something new. They checked patients’ spinal fluid for signs the immune system had fought an invading virus. Children who got sick had antibodies that target enteroviruses.
Dr. Michael Wilson is with the University of California, San Francisco. He helped lead the research. He said the evidence did not prove their idea. But it was a powerful sign enteroviruses cause AFM.
His team reported the findings in the publication Nature Medicine.
Study co-writer Dr. Riley Bove is with the same university as Wilson. Bove’s son developed AFM at age four. He noted, “If you don’t have a cause, you can’t have a vaccine.” Bove added that Wilson developed “a good enough microscope, in a sense, to find things they suspected were there.”
该研究的合著者莱利·波夫博士与威尔逊就职于同一所大学。波夫的儿子在四岁时患上了AFM。他指出：“如果没有病因，就不能接种疫苗。” 波夫补充说，威尔逊 “从某种意义上”，开发了“一种足够好的显微镜，通过它，他们可以观察他们怀疑的东西是否存在。”
About 590 cases of the illness have been confirmed in the U.S. since 2014. Cases increased that year, in 2016 and in 2018. Only a few were reported in the years in between. So far, there have been 22 cases this year.
Bove’s son Luca demonstrates the pattern. His whole family caught a cold in the summer of 2014. A few days later, Luca woke up with weakness in his neck that traveled down his shoulder. Within days, he had body-wide paralysis and trouble breathing. He recovered slowly. Today, he still has some paralysis in his neck, shoulder and arm.
Experts believe either a germ or the body’s reaction to a germ damages nerves in the spinal cords of patients like Luca. They are preparing for another possible increase of cases next summer.
I’m Jonathan Evans.